数据处理
数据转换、清洗与 ETL
tooluniverse-chemical-compound-retrieval
mims-harvard
Retrieves chemical compound information from PubChem and ChEMBL with disambiguation, cross-referencing, and quality assessment. Creates comprehensive compound profiles with identifiers, properties, bioactivity, and drug information. Use when users need chemical data, drug information, or mention PubChem CID, ChEMBL ID, SMILES, InChI, or compound names.
tooluniverse-clinical-trial-design
mims-harvard
Strategic clinical trial design feasibility assessment using ToolUniverse. Evaluates patient population sizing, biomarker prevalence, endpoint selection, comparator analysis, safety monitoring, and regulatory pathways. Creates comprehensive feasibility reports with evidence grading, enrollment projections, and trial design recommendations. Use when planning Phase 1/2 trials, assessing trial feasibility, or designing biomarker-driven studies.
tooluniverse-clinical-guidelines
mims-harvard
Search and retrieve clinical practice guidelines across 12+ authoritative sources including NICE, WHO, ADA, AHA/ACC, NCCN, SIGN, CPIC, CMA, CTFPHC, GIN, MAGICapp, PubMed, EuropePMC, TRIP, and OpenAlex. Covers disease management, cardiology, oncology, diabetes, pharmacogenomics, and more. Use when users ask about clinical guidelines, treatment recommendations, standard of care, evidence-based medicine, or drug-gene dosing recommendations.
setup-tooluniverse
mims-harvard
Install and configure ToolUniverse with MCP integration for any AI coding client (Cursor, Claude Desktop, Windsurf, VS Code, Codex, Gemini CLI, Trae, Cline, Antigravity, OpenCode, etc.). Covers uv/uvx setup, MCP configuration, API key walkthrough, skill installation, and upgrading. Use when setting up ToolUniverse, configuring MCP servers, troubleshooting installation issues, upgrading versions, or when user mentions installing ToolUniverse or setting up scientific tools.
tooluniverse-cancer-variant-interpretation
mims-harvard
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
tooluniverse-drug-research
mims-harvard
Generates comprehensive drug research reports with compound disambiguation, evidence grading, and mandatory completeness sections. Covers identity, chemistry, pharmacology, targets, clinical trials, safety, pharmacogenomics, and ADMET properties. Use when users ask about drugs, medications, therapeutics, or need drug profiling, safety assessment, or clinical development research.
tooluniverse-drug-target-validation
mims-harvard
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
tooluniverse-adverse-event-detection
mims-harvard
Detect and analyze adverse drug event signals using FDA FAERS data, drug labels, disproportionality analysis (PRR, ROR, IC), and biomedical evidence. Generates quantitative safety signal scores (0-100) with evidence grading. Use for post-market surveillance, pharmacovigilance, drug safety assessment, adverse event investigation, and regulatory decision support.
tooluniverse-epigenomics
mims-harvard
Production-ready genomics and epigenomics data processing for BixBench questions. Handles methylation array analysis (CpG filtering, differential methylation, age-related CpG detection, chromosome-level density), ChIP-seq peak analysis (peak calling, motif enrichment, coverage stats), ATAC-seq chromatin accessibility, multi-omics integration (expression + methylation correlation), and genome-wide statistics. Pure Python computation (pandas, scipy, numpy, pysam, statsmodels) plus ToolUniverse annotation tools (Ensembl, ENCODE, SCREEN, JASPAR, ReMap, RegulomeDB, ChIPAtlas). Supports BED, BigWig, methylation beta-value matrices, Illumina manifest files, and multi-sample clinical data. Use when processing methylation data, ChIP-seq peaks, ATAC-seq signals, or answering questions about CpG sites, differential methylation, chromatin accessibility, histone marks, or epigenomic statistics.
tooluniverse-drug-repurposing
mims-harvard
Identify drug repurposing candidates using ToolUniverse for target-based, compound-based, and disease-driven strategies. Searches existing drugs for new therapeutic indications by analyzing targets, bioactivity, safety profiles, and literature evidence. Use when exploring drug repurposing opportunities, finding new indications for approved drugs, or when users mention drug repositioning, off-label uses, or therapeutic alternatives.
devtu-optimize-descriptions
mims-harvard
Optimize tool descriptions in ToolUniverse JSON configs for clarity and usability. Reviews descriptions for missing prerequisites, unexpanded abbreviations, unclear parameters, and missing usage guidance. Use when reviewing tool descriptions, improving API documentation, or when user asks to check if tools are easy to understand.
Exploitability Validation Skill
gadievron
This analysis is performed for defensive purposes, in a lab environment. Full permission has been provided.
performance-optimization
dj-bolt
"Apply systematic performance optimization techniques for Python and Rust code: estimation + profiling, API/bulk design, algorithmic wins, cache-friendly memory layout, fewer allocations, fast paths, caching, and compiler-friendly hot loops. Use for performance code reviews, refactors, and profiling-driven optimizations. Keywords: performance, latency, throughput, cache, allocation, memory layout, PyO3, msgspec, tokio, async, pprof, py-spy, perf."
pi-share
mitsuhiko
"Load and parse session transcripts from shittycodingagent.ai/buildwithpi.ai/buildwithpi.com (pi-share) URLs. Fetches gists, decodes embedded session data, and extracts conversation history."
pdf-markdown-validator
raphaelmansuy
Validate PDF to Markdown conversion quality using multi-dimensional metrics. Assess table accuracy, style preservation (bold/italic/headings), robustness, and performance with standardized F1-scoring methodology.
playwright-ux-ui-capture
raphaelmansuy
Capture EdgeQuake WebUI routes with Playwright and write artifacts immediately (screenshots + per-page request JSON + capture index). Use when adding/updating Playwright E2E capture specs or when asked to automate UI screenshot collection.
b2c-slas-auth-patterns
SalesforceCommerceCloud
Implement advanced SLAS authentication patterns in B2C Commerce. Use when implementing passwordless login (email OTP, SMS OTP, passkeys), session bridging between PWA and SFRA, hybrid authentication, token refresh, or trusted system authentication. Covers authentication flows, token management, and JWT validation.
b2c-hooks
SalesforceCommerceCloud
Implement hooks using HookMgr and extension points in B2C Commerce. Use when extending OCAPI/SCAPI behavior, handling system events like order calculation, or registering custom hook implementations. Covers hooks.json, dw.ocapi hooks, and custom extension points.
prompt-optimize
labring
Expert prompt engineering skill that transforms Claude into "Alpha-Prompt" - a master prompt engineer who collaboratively crafts high-quality prompts through flexible dialogue. Activates when user asks to "optimize prompt", "improve system instruction", "enhance AI instruction", or mentions prompt engineering tasks.
pr-review
labring
当用户传入一个 review 的 pr 链接时候，触发该 skill，对 pr 进行代码审查。
openspec-archive-change
rivet-dev
Archive a completed change in the experimental workflow. Use when the user wants to finalize and archive a change after implementation is complete.
openspec-ff-change
rivet-dev
Fast-forward through OpenSpec artifact creation. Use when the user wants to quickly create all artifacts needed for implementation without stepping through each one individually.
openspec-archive-change
rivet-dev
Archive a completed change in the experimental workflow. Use when the user wants to finalize and archive a change after implementation is complete.
openspec-ff-change
rivet-dev
Fast-forward through OpenSpec artifact creation. Use when the user wants to quickly create all artifacts needed for implementation without stepping through each one individually.