Trending Skills
The hottest skills gaining momentum in the community right now.
数学建模技能 - Math Modeling
by XiaoMaColtAI
数学建模技能 - 为CUMCM、MCM/ICM等数学建模竞赛提供结构化的三阶段工作流程：建模分析、代码实现、论文撰写。包含丰富的算法资源库(优化/预测/评价/图论/机器学习等)、角色指导文档、论文模板和实用工具脚本。
huggingface-tokenizers
by NousResearch
Fast tokenizers optimized for research and production. Rust-based implementation tokenizes 1GB in <20 seconds. Supports BPE, WordPiece, and Unigram algorithms. Train custom vocabularies, track alignments, handle padding/truncation. Integrates seamlessly with transformers. Use when you need high-performance tokenization or custom tokenizer training.
gif-search
by NousResearch
Search and download GIFs from Tenor using curl. No dependencies beyond curl and jq. Useful for finding reaction GIFs, creating visual content, and sending GIFs in chat.
architecture-diagram
by pedronauck
Create professional, dark-themed architecture diagrams as standalone HTML files with SVG graphics. Use when the user asks for system architecture diagrams, infrastructure diagrams, cloud architecture visualizations, security diagrams, network topology diagrams, or any technical diagram showing system components and their relationships.
modal-serverless-gpu
by NousResearch
Serverless GPU cloud platform for running ML workloads. Use when you need on-demand GPU access without infrastructure management, deploying ML models as APIs, or running batch jobs with automatic scaling.
bio-similarity-searching
by GPTomics
Performs molecular similarity searches using Tanimoto coefficient on fingerprints via RDKit. Finds structurally similar compounds using ECFP or MACCS keys and clusters molecules by structural similarity using Butina clustering. Use when finding analogs of a query compound or clustering chemical libraries.
nature-reviewer
by Yuan1z0825
Simulate a Nature-style reviewer assessment from the referee perspective rather than an author rebuttal. Use when the user wants a pre-submission review, reviewer report, peer-review style critique, novelty/significance/technical soundness assessment, reviewer-style manuscript evaluation, 审稿人视角评估, 预审稿意见, or Nature reviewer report. Return 3 reviewer reports plus a cross-review synthesis, grounded only in the local Nature reviewer source basis. Also trigger on general pre-submission review requests during academic writing even without the word "Nature", such as getting a mock peer review for any journal, critiquing a draft as a reviewer would, assessing novelty/rigor before submission, and Chinese phrasings like 审稿人视角、模拟审稿、预审、帮我审一下论文、投稿前自审、审稿意见模拟、找论文问题.
ui-ux-pro-max
by nextlevelbuilder
"UI/UX design intelligence for web and mobile. Includes 50+ styles, 161 color palettes, 57 font pairings, 161 product types, 99 UX guidelines, and 25 chart types across 10 stacks (React, Next.js, Vue, Svelte, SwiftUI, React Native, Flutter, Tailwind, shadcn/ui, and HTML/CSS). Actions: plan, build, create, design, implement, review, fix, improve, optimize, enhance, refactor, and check UI/UX code. Projects: website, landing page, dashboard, admin panel, e-commerce, SaaS, portfolio, blog, and mobile app. Elements: button, modal, navbar, sidebar, card, table, form, and chart. Styles: glassmorphism, claymorphism, minimalism, brutalism, neumorphism, bento grid, dark mode, responsive, skeuomorphism, and flat design. Topics: color systems, accessibility, animation, layout, typography, font pairing, spacing, interaction states, shadow, and gradient. Integrations: shadcn/ui MCP for component search and examples."
cartography
by alvinunreal
Repository understanding and hierarchical codemap generation
typescript-magician
by mcollina
TypeScript wizard specializing in advanced type systems, complex generics, and eliminating any types
solidity-auditor
by pashov
Security audit of Solidity code while you develop. Trigger on "audit", "check this contract", "review for security". Modes - default (full repo) or a specific filename.
bio-substructure-search
by GPTomics
Searches molecular libraries for substructure matches using SMARTS patterns with RDKit. Filters compounds by pharmacophore features, functional groups, or scaffold matches with atom mapping. Use when finding compounds containing specific chemical moieties or filtering libraries by structural features.
bio-reaction-enumeration
by GPTomics
Enumerates chemical libraries through reaction SMARTS transformations using RDKit. Generates virtual compound libraries from building blocks using defined chemical reactions with product validation. Use when creating combinatorial libraries or enumerating products from synthetic routes.
bio-clinical-databases-dbsnp-queries
by GPTomics
Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
bio-atac-seq-nucleosome-positioning
by GPTomics
Extract nucleosome positions from ATAC-seq data using NucleoATAC, ATACseqQC, and fragment analysis. Use when analyzing chromatin organization, identifying nucleosome-free regions at promoters, or characterizing nucleosome occupancy patterns from ATAC-seq fragment size distributions.
bio-causal-genomics-colocalization-analysis
by GPTomics
Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals. Use when determining if a GWAS signal and an eQTL share the same causal variant.
bio-clinical-databases-myvariant-queries
by GPTomics
Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request. Use when annotating variants with clinical and population data from multiple sources simultaneously.
bio-clinical-databases-clinvar-lookup
by GPTomics
Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
bio-chipseq-qc
by GPTomics
ChIP-seq quality control metrics including FRiP (Fraction of Reads in Peaks), cross-correlation analysis (NSC/RSC), library complexity, and IDR (Irreproducibility Discovery Rate) for replicate concordance. Use to assess experiment quality before downstream analysis. Use when assessing ChIP-seq data quality metrics.
bio-splicing-qc
by GPTomics
Assesses RNA-seq data quality for splicing analysis including junction saturation curves, splice site strength scoring, and junction coverage metrics using RSeQC. Use when evaluating data suitability for splicing analysis or troubleshooting low event detection.
bio-causal-genomics-mediation-analysis
by GPTomics
Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular phenotype mediates the genotype-to-phenotype relationship.
bio-atac-seq-atac-qc
by GPTomics
Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity. Use when assessing ATAC-seq library quality before or after peak calling to identify problematic samples.
bio-causal-genomics-mendelian-randomization
by GPTomics
Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
bio-atac-seq-footprinting
by GPTomics
Detect transcription factor binding sites through footprinting analysis in ATAC-seq data using TOBIAS. Use when identifying TF occupancy patterns within accessible regions, as TF binding protects DNA from Tn5 cutting.