Processing
Data transformation and parsing
unity-navmesh
by Besty0728
"Navigation mesh operations. Use when users want to bake NavMesh or calculate paths for AI navigation. Triggers: navmesh, navigation, pathfinding, bake, AI, agent, obstacle, 导航网格, 寻路, 烘焙."
blog-rewrite
by AgriciDaniel
Rewrite and optimize existing blog posts for Google rankings (December 2025 Core Update, E-E-A-T) and AI citations (GEO/AEO). Replaces fabricated statistics with sourced data, applies answer-first formatting, adds Pixabay/Unsplash images, generates built-in SVG charts, injects FAQ schema, performs AI content detection, adds citation capsules and information gain markers, and updates freshness signals. Works with any blog format (MDX, markdown, HTML). Use when user says "rewrite blog", "optimize blog", "update blog", "improve blog", "fix blog", "refresh blog post", "blog optimization".
clay-multi-env-setup
by Dicklesworthstone
Configure Clay across development, staging, and production environments. Use when setting up multi-environment deployments, configuring per-environment secrets, or implementing environment-specific Clay configurations. Trigger with phrases like "clay environments", "clay staging", "clay dev prod", "clay environment setup", "clay config by env".
i18n
by iOfficeAI
Internationalization (i18n) workflow and standards for managing translations. Use when: (1) Adding new user-facing text, (2) Creating new components with text, (3) Reviewing code for i18n compliance. Features: Key naming conventions, sync checking, hardcoded string detection, translation workflow.
yuanbao
by NousResearch
"Yuanbao (元宝) groups: @mention users, query info/members."
xlsx
by iOfficeAI
'Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization. When Claude needs to work with spreadsheets (.xlsx, .xlsm, .csv, .tsv, etc) for: (1) Creating new spreadsheets with formulas and formatting, (2) Reading or analyzing data, (3) Modify existing spreadsheets while preserving formulas, (4) Data analysis and visualization in spreadsheets, or (5) Recalculating formulas'
markdown-converter
by steipete
Convert documents and files to Markdown using markitdown. Use when converting PDF, Word (.docx), PowerPoint (.pptx), Excel (.xlsx, .xls), HTML, CSV, JSON, XML, images (with EXIF/OCR), audio (with transcription), ZIP archives, YouTube URLs, or EPubs to Markdown format for LLM processing or text analysis.
clay-data-handling
by Dicklesworthstone
Implement Clay PII handling, data retention, and GDPR/CCPA compliance patterns. Use when handling sensitive data, implementing data redaction, configuring retention policies, or ensuring compliance with privacy regulations for Clay integrations. Trigger with phrases like "clay data", "clay PII", "clay GDPR", "clay data retention", "clay privacy", "clay CCPA".
market-research
by affaan-m
Conduct market research, competitive analysis, investor due diligence, and industry intelligence with source attribution and decision-oriented summaries. Use when the user wants market sizing, competitor comparisons, fund research, technology scans, or research that informs business decisions.
story-roleplay
by iOfficeAI
Parse and apply character cards and world info files in multiple formats (PNG, WebP, JSON), fully compatible with SillyTavern format. Supports automatic parsing, keyword triggering, and dynamic updates.
tooluniverse-multi-omics-integration
by mims-harvard
Integrate and analyze multiple omics datasets (transcriptomics, proteomics, epigenomics, genomics, metabolomics) for systems biology and precision medicine. Performs cross-omics correlation, multi-omics clustering (MOFA+, NMF), pathway-level integration, and sample matching. Coordinates ToolUniverse skills for expression data (RNA-seq), epigenomics (methylation, ChIP-seq), variants (SNVs, CNVs), protein interactions, and pathway enrichment. Use when analyzing multi-omics datasets, performing integrative analysis, discovering multi-omics biomarkers, studying disease mechanisms across molecular layers, or conducting systems biology research that requires coordinated analysis of transcriptome, genome, epigenome, proteome, and metabolome data.
devtu-optimize-skills
by mims-harvard
Optimize ToolUniverse skills for better report quality, evidence handling, and user experience. Apply patterns like tool verification, foundation data layers, disambiguation-first, evidence grading, quantified completeness, and report-only output. Use when reviewing skills, improving existing skills, or creating new ToolUniverse research skills.
tooluniverse-precision-medicine-stratification
by mims-harvard
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
tooluniverse-image-analysis
by mims-harvard
Production-ready microscopy image analysis and quantitative imaging data skill for colony morphometry, cell counting, fluorescence quantification, and statistical analysis of imaging-derived measurements. Processes ImageJ/CellProfiler output (area, circularity, intensity, cell counts), performs Dunnett's test, Cohen's d effect size, power analysis, Shapiro-Wilk normality tests, two-way ANOVA, polynomial regression, natural spline regression with confidence intervals, and comparative morphometry. Supports CSV/TSV measurement tables, multi-channel fluorescence data, colony swarming assays, and neuron counting datasets. Use when analyzing microscopy measurement data, colony area/circularity, cell count statistics, swarming assays, co-culture ratio optimization, or answering questions about imaging-derived quantitative data.
tooluniverse-chemical-compound-retrieval
by mims-harvard
Retrieves chemical compound information from PubChem and ChEMBL with disambiguation, cross-referencing, and quality assessment. Creates comprehensive compound profiles with identifiers, properties, bioactivity, and drug information. Use when users need chemical data, drug information, or mention PubChem CID, ChEMBL ID, SMILES, InChI, or compound names.
tooluniverse-multiomic-disease-characterization
by mims-harvard
Comprehensive multi-omics disease characterization integrating genomics, transcriptomics, proteomics, pathway, and therapeutic layers for systems-level understanding. Produces a detailed multi-omics report with quantitative confidence scoring (0-100), cross-layer gene concordance analysis, biomarker candidates, therapeutic opportunities, and mechanistic hypotheses. Uses 80+ ToolUniverse tools across 8 analysis layers. Use when users ask about disease mechanisms, multi-omics analysis, systems biology of disease, biomarker discovery, or therapeutic target identification from a disease perspective.
tooluniverse-metabolomics-analysis
by mims-harvard
Analyze metabolomics data including metabolite identification, quantification, pathway analysis, and metabolic flux. Processes LC-MS, GC-MS, NMR data from targeted and untargeted experiments. Performs normalization, statistical analysis, pathway enrichment, metabolite-enzyme integration, and biomarker discovery. Use when analyzing metabolomics datasets, identifying differential metabolites, studying metabolic pathways, integrating with transcriptomics/proteomics, discovering metabolic biomarkers, performing flux balance analysis, or characterizing metabolic phenotypes in disease, drug response, or physiological conditions.
tooluniverse-immunotherapy-response-prediction
by mims-harvard
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
tooluniverse-cancer-variant-interpretation
by mims-harvard
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
tooluniverse-metabolomics
by mims-harvard
Comprehensive metabolomics research skill for identifying metabolites, analyzing studies, and searching metabolomics databases. Integrates HMDB (220k+ metabolites), MetaboLights, Metabolomics Workbench, and PubChem. Use when asked to identify or annotate metabolites (HMDB IDs, chemical properties, pathways), retrieve metabolomics study information from MetaboLights (MTBLS*) or Metabolomics Workbench (ST*), search for studies by keywords or disease, or generate comprehensive metabolomics research reports.
tooluniverse-chemical-safety
by mims-harvard
Comprehensive chemical safety and toxicology assessment integrating ADMET-AI predictions, CTD toxicogenomics, FDA label safety data, DrugBank safety profiles, and STITCH chemical-protein interactions. Performs predictive toxicology (AMES, DILI, LD50, carcinogenicity), organ/system toxicity profiling, chemical-gene-disease relationship mapping, regulatory safety extraction, and environmental hazard assessment. Use when asked about chemical toxicity, drug safety profiling, ADMET properties, environmental health risks, chemical hazard assessment, or toxicogenomic analysis.
tooluniverse-drug-target-validation
by mims-harvard
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
API Fuzzing for Bug Bounty
by sickn33
This skill should be used when the user asks to "test API security", "fuzz APIs", "find IDOR vulnerabilities", "test REST API", "test GraphQL", "API penetration testing", "bug bounty API testing", or needs guidance on API security assessment techniques.
api-documentation-generator
by sickn33
"Generate comprehensive, developer-friendly API documentation from code, including endpoints, parameters, examples, and best practices"