Database
Database management and queries
bio-clinical-databases-myvariant-queries
by GPTomics
Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request. Use when annotating variants with clinical and population data from multiple sources simultaneously.
bio-clinical-databases-clinvar-lookup
by GPTomics
Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
bio-clinical-databases-dbsnp-queries
by GPTomics
Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
pragmatic-programmer
by wondelai
'Apply meta-principles of software craftsmanship: DRY, orthogonality, tracer bullets, and design by contract. Use when the user mentions "best practices", "pragmatic approach", "broken windows", "tracer bullet", or "software craftsmanship". Covers estimation, domain languages, and reversibility. For code-level quality, see clean-code. For refactoring techniques, see refactoring-patterns.'
clean-architecture
by wondelai
'Structure software around the Dependency Rule: source code dependencies point inward from frameworks to use cases to entities. Use when the user mentions "architecture layers", "dependency rule", "ports and adapters", "hexagonal architecture", "use case boundary", "onion architecture", "screaming architecture", or "framework independence". Also trigger when decoupling business logic from databases or frameworks, defining module boundaries, or debating where to put business rules. Covers component principles, boundaries, and SOLID. For code quality, see clean-code. For domain modeling, see domain-driven-design.'
secure-code-review
by Ed1s0nZ
安全代码审查的专业技能和方法论
ddia-systems
by wondelai
'Design data systems by understanding storage engines, replication, partitioning, transactions, and consistency models. Use when the user mentions "database choice", "replication lag", "partitioning strategy", "consistency vs availability", or "stream processing". Covers data models, batch/stream processing, and distributed consensus. For system design, see system-design. For resilience, see release-it.'
godot-3d-materials
by thedivergentai
"Expert patterns for Godot 3D PBR materials using StandardMaterial3D including albedo, metallic/roughness workflows, normal maps, ORM texture packing, transparency modes, and shader conversion. Use when creating realistic 3D surfaces, PBR workflows, or material optimization. Trigger keywords: StandardMaterial3D, BaseMaterial3D, albedo_texture, metallic, metallic_texture, roughness, roughness_texture, normal_texture, normal_enabled, orm_texture, transparency, alpha_scissor, alpha_hash, cull_mode, ShaderMaterial, shader parameters."
bio-alignment-pairwise
by GPTomics
Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and identifying local or global matches between DNA, RNA, or protein sequences.
go-architect
by existential-birds
Go application architecture with net/http 1.22+ routing, project structure patterns, graceful shutdown, and dependency injection. Use when building Go web servers, designing project layout, or structuring application dependencies.
seo-competitor-pages
by AgriciDaniel
Generate SEO-optimized competitor comparison and alternatives pages. Covers "X vs Y" layouts, "alternatives to X" pages, feature matrices, schema markup, and conversion optimization. Use when user says "comparison page", "vs page", "alternatives page", "competitor comparison", or "X vs Y".
chroma
by NousResearch
Open-source embedding database for AI applications. Store embeddings and metadata, perform vector and full-text search, filter by metadata. Simple 4-function API. Scales from notebooks to production clusters. Use for semantic search, RAG applications, or document retrieval. Best for local development and open-source projects.
godot-2d-physics
by thedivergentai
"Expert patterns for Godot 2D physics including collision layers/masks, Area2D triggers, raycasting, and PhysicsDirectSpaceState2D queries. Use when implementing collision detection, trigger zones, line-of-sight systems, or manual physics queries. Trigger keywords: CollisionShape2D, CollisionPolygon2D, collision_layer, collision_mask, set_collision_layer_value, set_collision_mask_value, Area2D, body_entered, body_exited, RayCast2D, force_raycast_update, PhysicsPointQueryParameters2D, PhysicsShapeQueryParameters2D, direct_space_state, move_and_collide, move_and_slide."
drizzle-safe-migrations
by pedronauck
Production-safe Drizzle migration workflow for schema changes that require data backfills or constraint tightening. Use when changing enums/check constraints/defaults, removing status values, or sequencing custom and generated migrations in Drizzle. Trigger on requests about Drizzle migration safety, deployment-safe backfills, migration ordering, and rollback planning.
pinecone
by NousResearch
Managed vector database for production AI applications. Fully managed, auto-scaling, with hybrid search (dense + sparse), metadata filtering, and namespaces. Low latency (<100ms p95). Use for production RAG, recommendation systems, or semantic search at scale. Best for serverless, managed infrastructure.
drizzle
by lobehub
Drizzle ORM schema and database guide. Use when working with database schemas (src/database/schemas/*), defining tables, creating migrations, or database model code. Triggers on Drizzle schema definition, database migrations, or ORM usage questions.
alphafold-database
by Microck
"Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology."
cellxgene-census
by K-Dense-AI
Query the CELLxGENE Census (61M+ cells) programmatically. Use when you need expression data across tissues, diseases, or cell types from the largest curated single-cell atlas. Best for population-scale queries, reference atlas comparisons. For analyzing your own data use scanpy or scvi-tools.
testing
by lobehub
Testing guide using Vitest. Use when writing tests (.test.ts, .test.tsx), fixing failing tests, improving test coverage, or debugging test issues. Triggers on test creation, test debugging, mock setup, or test-related questions.
notion
by NousResearch
Notion API for creating and managing pages, databases, and blocks via curl. Search, create, update, and query Notion workspaces directly from the terminal.
databricks-synthetic-data-generation
by databricks-solutions
"Generate realistic synthetic data using Faker and Spark, with non-linear distributions, integrity constraints, and save to Databricks. Use when creating test data, demo datasets, or synthetic tables."
AgentDB Vector Search
by Microck
"Implement semantic vector search with AgentDB for intelligent document retrieval, similarity matching, and context-aware querying. Use when building RAG systems, semantic search engines, or intelligent knowledge bases."
andrew-kane-gem-writer
by Microck
Write Ruby gems following Andrew Kane's proven patterns and philosophy. Use when creating new Ruby gems, refactoring existing gems, designing gem APIs, or when the user wants clean, minimal, production-ready Ruby library code. Triggers on requests like "create a gem", "write a Ruby library", "design a gem API", or mentions of Andrew Kane's style.
Backend Models Standards
by Microck
Define database models with clear naming, appropriate data types, constraints, relationships, and validation at multiple layers. Use this skill when creating or modifying database model files, ORM classes, schema definitions, or data model relationships. Apply when working with model files (e.g., models.py, models/, ActiveRecord classes, Prisma schema, Sequelize models), defining table structures, setting up foreign keys and relationships, configuring cascade behaviors, implementing model validations, adding timestamps, or working with database constraints (NOT NULL, UNIQUE, foreign keys). Use for any task involving data integrity enforcement, relationship definitions, or model-level data validation.