Tipus
Comprovació i generació de tipus
tooluniverse-polygenic-risk-score
mims-harvard
Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics. Calculates genetic risk profiles, interprets PRS percentiles, and assesses disease predisposition across conditions including type 2 diabetes, coronary artery disease, and Alzheimer's disease. Use when asked to calculate polygenic risk scores, interpret genetic risk for complex diseases, build custom PRS from GWAS data, or answer questions like "What is my genetic predisposition to breast cancer?"
tooluniverse-gene-enrichment
mims-harvard
Perform comprehensive gene enrichment and pathway analysis using gseapy (ORA and GSEA), PANTHER, STRING, Reactome, and 40+ ToolUniverse tools. Supports GO enrichment (BP, MF, CC), KEGG, Reactome, WikiPathways, MSigDB Hallmark, and 220+ Enrichr libraries. Handles multiple ID types (gene symbols, Ensembl, Entrez, UniProt), multiple organisms (human, mouse, rat, fly, worm, yeast), customizable backgrounds, and multiple testing correction (BH, Bonferroni). Use when users ask about gene enrichment, pathway analysis, GO term enrichment, KEGG pathway analysis, GSEA, over-representation analysis, functional annotation, or gene set analysis.
tooluniverse-gwas-drug-discovery
mims-harvard
Transform GWAS signals into actionable drug targets and repurposing opportunities. Performs locus-to-gene mapping, target druggability assessment, existing drug identification, safety profile evaluation, and clinical trial matching. Use when discovering drug targets from GWAS data, finding drug repurposing opportunities from genetic associations, or translating GWAS findings into therapeutic leads.
devtu-auto-discover-apis
mims-harvard
Automatically discover life science APIs online, create ToolUniverse tools, validate them, and prepare integration PRs. Performs gap analysis to identify missing tool categories, web searches for APIs, automated tool creation using devtu-create-tool patterns, validation with devtu-fix-tool, and git workflow management. Use when expanding ToolUniverse coverage, adding new API integrations, or systematically discovering scientific resources.
tooluniverse-gwas-finemapping
mims-harvard
Identify and prioritize causal variants at GWAS loci using statistical fine-mapping and locus-to-gene predictions. Computes posterior probabilities for causal variants, links variants to genes via L2G predictions, annotates functional consequences, and suggests validation strategies. Use when asked to fine-map GWAS loci, prioritize causal variants, identify credible sets, or link GWAS signals to causal genes.
devtu-create-tool
mims-harvard
Create new scientific tools for ToolUniverse framework with proper structure, validation, and testing. Use when users need to add tools to ToolUniverse, implement new API integrations, create tool wrappers for scientific databases/services, expand ToolUniverse capabilities, or follow ToolUniverse contribution guidelines. Supports creating tool classes, JSON configurations, validation, error handling, and test examples.
tooluniverse-precision-oncology
mims-harvard
Provide actionable treatment recommendations for cancer patients based on molecular profile. Interprets tumor mutations, identifies FDA-approved therapies, finds resistance mechanisms, matches clinical trials. Use when oncologist asks about treatment options for specific mutations (EGFR, KRAS, BRAF, etc.), therapy resistance, or clinical trial eligibility.
meeting-minutes
github
'Generate concise, actionable meeting minutes for internal meetings. Includes metadata, attendees, agenda, decisions, action items (owner + due date), and follow-up steps.'
code-exemplars-blueprint-generator
github
'Technology-agnostic prompt generator that creates customizable AI prompts for scanning codebases and identifying high-quality code exemplars. Supports multiple programming languages (.NET, Java, JavaScript, TypeScript, React, Angular, Python) with configurable analysis depth, categorization methods, and documentation formats to establish coding standards and maintain consistency across development teams.'
copilot-sdk
github
Build agentic applications with GitHub Copilot SDK. Use when embedding AI agents in apps, creating custom tools, implementing streaming responses, managing sessions, connecting to MCP servers, or creating custom agents. Triggers on Copilot SDK, GitHub SDK, agentic app, embed Copilot, programmable agent, MCP server, custom agent.
dagger-design-proposals
dagger
Write design proposals for Dagger features. Use when asked to draft, review, or iterate on Dagger design documents, RFCs, or proposals.
reverse-documentation
raphaelmansuy
Automatically generate comprehensive documentation for Rust and TypeScript codebases by analyzing code structure, patterns, and relationships. Supports trait-based patterns, async operations, React components, and Next.js applications.
doc-traceability-validator
raphaelmansuy
Validate documentation traceability between code annotations (@implements), feature registry, business rules, and use cases. Detect ID collisions, undocumented features, broken cross-references, and namespace violations.
copilotkit-nextjs-integration
raphaelmansuy
Integrate CopilotKit AI components into Next.js frontend for building agentic UIs. Enables context-aware AI agents that can read app state and trigger tools/actions. Supports custom adapters for self-hosted LLMs and multiple provider integrations.
m05-type-driven
actionbook
"CRITICAL: Use for type-driven design. Triggers: type state, PhantomData, newtype, marker trait, builder pattern, make invalid states unrepresentable, compile-time validation, sealed trait, ZST, 类型状态, 新类型模式, 类型驱动设计"
m09-domain
actionbook
"CRITICAL: Use for domain modeling. Triggers: domain model, DDD, domain-driven design, entity, value object, aggregate, repository pattern, business rules, validation, invariant, 领域模型, 领域驱动设计, 业务规则"
alembic
TerminalSkills
Manage database migrations with Alembic. Use when a user asks to version database schemas, create migration scripts, handle schema changes in production, or manage SQLAlchemy model migrations.
allium
juxt
An LLM-native language for sharpening intent alongside implementation. Velocity through clarity.
to-spring-or-not-to-spring
raphaelsalaja
Audit animation code for correct timing function selection. Use when reviewing motion implementations, debugging animations that feel wrong, or choosing between springs and easing. Outputs file:line findings.
aspnet-minimal-api-openapi
github
'Create ASP.NET Minimal API endpoints with proper OpenAPI documentation'
conventional-commit
github
'Prompt and workflow for generating conventional commit messages using a structured XML format. Guides users to create standardized, descriptive commit messages in line with the Conventional Commits specification, including instructions, examples, and validation.'
git-commit
github
'Execute git commit with conventional commit message analysis, intelligent staging, and message generation. Use when user asks to commit changes, create a git commit, or mentions "/commit". Supports: (1) Auto-detecting type and scope from changes, (2) Generating conventional commit messages from diff, (3) Interactive commit with optional type/scope/description overrides, (4) Intelligent file staging for logical grouping'
terraform-azurerm-set-diff-analyzer
github
Analyze Terraform plan JSON output for AzureRM Provider to distinguish between false-positive diffs (order-only changes in Set-type attributes) and actual resource changes. Use when reviewing terraform plan output for Azure resources like Application Gateway, Load Balancer, Firewall, Front Door, NSG, and other resources with Set-type attributes that cause spurious diffs due to internal ordering changes.
azure-deployment-preflight
github
'Performs comprehensive preflight validation of Bicep deployments to Azure, including template syntax validation, what-if analysis, and permission checks. Use this skill before any deployment to Azure to preview changes, identify potential issues, and ensure the deployment will succeed. Activate when users mention deploying to Azure, validating Bicep files, checking deployment permissions, previewing infrastructure changes, running what-if, or preparing for azd provision.'