covalent-probe-discovery
by mr-johnee
"Systematic literature-mining pipeline for discovering novel covalent reactive handles capable of forming stable bonds with specified biological side-chain functionalities (including cysteine, lysine, serine, histidine, tyrosine, threonine, aspartate, glutamate, and methionine) under intended probe-use conditions. Use when a user asks to survey recent chemistry literature for novel covalent reaction partners targeting a specific residue or functional group, search for side-chain-reactive covalent motifs, design new reactive handles for chemical probes or covalent ligands, or produce an academic report of novel candidates with validated SMILES, rendered structures, and primary-literature citations."